Energy regeneration from suspension dynamic modes and self-powered actuation

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.This paper concerns energy harvesting from vehicle suspension systems. The generated power associated with bounce, pitch and roll modes of vehicle dynamics is determined through analysis. The potential values of power generation from these three modes are calculated. Next, experiments are carried out using a vehicle with a four jack shaker rig to validate the analytical values of potential power harvest. For the considered vehicle, maximum theoretical power values of 1.1kW, 0.88kW and 0.97kW are associated with the bounce, pitch and roll modes, respectively, at 20 Hz excitation frequency and peak to peak displacement amplitude of 5 mm at each wheel, as applied by the shaker. The corresponding experimentally power values are 0.98kW, 0.74kW and 0.78kW. An experimental rig is also developed to study the behavior of regenerative actuators in generating electrical power from kinetic energy. This rig represents a quarter-vehicle suspension model where the viscous damper in the shock absorber system is replaced by a regenerative system. The rig is able to demonstrate the actual electrical power that can be harvested using a regenerative system. The concept of self-powered actuation using the harvested energy from suspension is discussed with regard to applications of self-powered vibration control. The effect of suspension energy regeneration on ride comfort and road handling is presented in conjunction with energy harvesting associated with random road excitations.Peer reviewedFinal Accepted Versio

Energy-band engineering for improved charge retention in fully self-aligned double floating-gate single-electron memories

We present a new fully self-aligned single-electron memory with a single pair of nano floating gates, made of different materials (Si and Ge). The energy barrier that prevents stored charge leakage is induced not only by quantum effects but also by the conduction-band offset that arises between Ge and Si. The dimension and position of each floating gate are well defined and controlled. The devices exhibit a long retention time and single-electron injection at room temperature

Susceptibility of HIV-1 Subtypes B′, CRF07_BC and CRF01_AE that Are Predominantly Circulating in China to HIV-1 Entry Inhibitors

The B', CRF07_BC and CRF01_AE are the predominant HIV-1 subtypes in China. It is essential to determine their baseline susceptibility to HIV entry inhibitors before these drugs are used in China.The baseline susceptibility of 14 representative HIV-1 isolates (5 CRF07_BC, 4 CRF01_AE, and 5 B'), most of which were R5 viruses, obtained from drug-naïve patients to HIV entry inhibitors, including two fusion inhibitors (enfuvirtide and C34), two CCR5 antagonists (maraviroc and TAK779) and one CXCR4 antagonist (AMD3100), were determined by virus inhibition assay. The sequences of their env genes were amplified and analyzed. These isolates possessed similar susceptibility to C34, but they exhibited different sensitivity to enfuvirtide, maraviroc or TAK779. CRF07_BC isolates, which carried polymorphisms of A578T and V583I in the N-terminal heptad repeat and E630Q, E662A, K665S, A667K and S668N in the C-terminal heptad repeat of gp41, were about 5-fold less sensitive than B' and CRF01_AE isolates to enfuvirtide. Subtype B' isolates with a unique polymorphism site of F317W in V3 loop, were about 4- to 5-fold more sensitive than CRF07_BC and CRF01_AE isolates to maraviroc and TAK779. AMD3100 at the concentration as high as 5 µM exhibited no significant inhibitory activity against any of the isolates tested.Our results suggest that there are significant differences in baseline susceptibility to HIV entry inhibitors among the predominant HIV-1 subtypes in China and the differences may partly result from the naturally occurring polymorphisms in these subtypes. This study provides useful information for rational design of optimal therapeutic regimens for HIV-1-infected patients in China

Removal of non-CO2 greenhouse gases by large-scale atmospheric solar photocatalysis

Large-scale atmospheric removal of greenhouse gases (GHGs) including methane, nitrous oxide and ozone-depleting halocarbons could reduce global warming more quickly than atmospheric removal of CO2. Photocatalysis of methane oxidizes it to CO2, effectively reducing its global warming potential (GWP) by at least 90%. Nitrous oxide can be reduced to nitrogen and oxygen by photocatalysis; meanwhile halocarbons can be mineralized by red-ox photocatalytic reactions to acid halides and CO2. Photocatalysis avoids the need for capture and sequestration of these atmospheric components. Here review an unusual hybrid device combining photocatalysis with carbon-free electricity with no-intermittency based on the solar updraft chimney. Then we review experimental evidence regarding photocatalytic transformations of non-CO2 GHGs. We propose to combine TiO2-photocatalysis with solar chimney power plants (SCPPs) to cleanse the atmosphere of non-CO2 GHGs. Worldwide installation of 50,000 SCPPs, each of capacity 200 MW, would generate a cumulative 34 PWh of renewable electricity by 2050, taking into account construction time. These SCPPs equipped with photocatalyst would process 1 atmospheric volume each 14–16 years, reducing or stopping the atmospheric growth rate of the non-CO2 GHGs and progressively reducing their atmospheric concentrations. Removal of methane, as compared to other GHGs, has enhanced efficacy in reducing radiative forcing because it liberates more °OH radicals to accelerate the cleaning of the troposphere. The overall reduction in non-CO2 GHG concentration would help to limit global temperature rise. By physically linking greenhouse gas removal to renewable electricity generation, the hybrid concept would avoid the moral hazard associated with most other climate engineering proposals

Heat Shock Proteins and Amateur Chaperones in Amyloid-Beta Accumulation and Clearance in Alzheimer’s Disease

The pathologic lesions of Alzheimer’s disease (AD) are characterized by accumulation of protein aggregates consisting of intracellular or extracellular misfolded proteins. The amyloid-β (Aβ) protein accumulates extracellularly in senile plaques and cerebral amyloid angiopathy, whereas the hyperphosphorylated tau protein accumulates intracellularly as neurofibrillary tangles. “Professional chaperones”, such as the heat shock protein family, have a function in the prevention of protein misfolding and subsequent aggregation. “Amateur” chaperones, such as apolipoproteins and heparan sulfate proteoglycans, bind amyloidogenic proteins and may affect their aggregation process. Professional and amateur chaperones not only colocalize with the pathological lesions of AD, but may also be involved in conformational changes of Aβ, and in the clearance of Aβ from the brain via phagocytosis or active transport across the blood–brain barrier. Thus, both professional and amateur chaperones may be involved in the aggregation, accumulation, persistence, and clearance of Aβ and tau and in other Aβ-associated reactions such as inflammation associated with AD lesions, and may, therefore, serve as potential targets for therapeutic intervention

An investigation into high-load SFI EGR boosted operation for downsized GTDI engine with valve-overlap reduction

This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonDownsized gasoline turbocharged direct injection (GTDI) engines deliver superior fuel economy by operating the engine at higher loads but become prone to knocking combustion at boosted operations, which requires the application of knock mitigation strategies, such as the retarded spark timing, with a negative impact on the engine performance and efficiency. Furthermore, the use of wide valve-overlaps to maximise positive scavenging by elevated intake pressure at low and medium engine speeds leads to greater tailpipe NOx emissions. In light of increased use of Real Driving Emissions (RDE) test where higher load operations are far more prominent, there is a strong need to further explore the approaches to improve engine efficiency and lower harmful emissions at knock limited operations. This project investigates the use of stratified flame ignition (SFI) combustion with exhaust gas recirculation (EGR) on a downsized GTDI engine. EGR dilution is added to control the knocking combustion to replace the traditional knock mitigation strategies. The subsequent combustion is further improved by stratified fuel injection and uprated ignition system. The valve-overlap duration is shortened to avoid the air short-circuiting and hence reduced tailpipe NOx emission through greater conversion efficiency of the 3-way catalyst, but with trade-off with lower volumetric efficiency and knock onset. The novelty of the study is identified as the combination and optimisation of these strategies to improve operational efficiency and reduce harmful tailpipe emissions at knock limited loads. The results showed that the EGR dilution lowered knock tendency and high energy (HE) ignition accelerated the combustion and recovered stability exclusively at boosted operations. Split injection strategy showed fuel consumption benefit at very limited cases, and most cases led to the loss of efficiency from slower less efficient combustion. Through computational fluid dynamics (CFD) analysis, this was found to be caused by the unfavourable mixture preparation of the multi-hole injectors due to high spray penetration and insufficient mixture preparation time. However, the combined use of EGR dilution and reduced valve-overlap improved mixture preparation due to increased charge temperatures and induced turbulence. Indicated specific fuel consumption (ISFC) improvements of 4.8% and 5.2% were achieved at 13.7bar and 16.4bar Net_IMEP at 2000rpm, respectively. The reduction of valve-overlap also improved the combustion efficiency and reduced emissions of tailpipe NOx and particulates due to eliminated short-circuit air and enhanced turbulence for faster mixture preparation. Hence, a synergy between valve-overlap reduction, split injection, and EGR dilution was found, and the proposed strategy successfully lowered fuel consumption and harmful emissions from this combined synergy effect.Ford Motor Corporation University Research Progra